About

Kenneth J. Laszlo, Ph.D.

Education and Work experience

Technology Development Engineer | Intel | Hillsboro, OR July 2017 – Present

Ph. D | Chemistry | University of Washington | Seattle, WA June 2017

Advised by Prof. Matthew F. Bush

GPA: 3.8

B.S. | Chemistry | Georgia Institute of Technology | Atlanta, GA Graduated May 2012Summa Cum Laude | GPA: 3.65

Research option advised by Associate Prof. Facundo Fernandéz

Publications

12. Canzani, Daniele, Kenneth J. Laszlo, Matthew F. Bush. “Ion Mobility of Proteins in Nitrogen Gas: Effects of Charge State, Charge Distribution, and Structure”, J. Phys. Chem. A,  2018, 122, 5625-5634. DOI: 10.1021/acs.jpca.8b04474

11. Laszlo, Kenneth J., Matthew F. Bush. “Effects of Charge State, Charge Distribution, and Structure on the Ion Mobility of Protein Ions in Helium Gas: Results from Trajectory Method Calculations”, J. Phys. Chem. A,  2017, 121, 7768-7777. DOI: 10.1021/acs.jpca.7b08154

10. Laszlo, Kenneth J., Matthew F. Bush. “Interpreting the Collision Cross Sections of Native-Like Protein Ions: Insights from Cation-to-Anion Proton-Transfer Reactions”, Anal. Chem., 2017, 89, 7606-7614.DOI: 10.1021/acs.analchem.7b01474 

9. Laszlo, Kenneth J, Eleanor B. Munger, and Matthew F Bush. “Effects of Solution Structure on the Folding of Lysozyme Ions in the Gas Phase.” J. Phys. Chem. B, 2017, 121, 2759-2766. DOI:10.1021/acs.jpcb.7b00783.

8. Laszlo, Kenneth J., John H. Buckner, Eleanor B. Munger, and Matthew F. Bush. “Native-like and Denatured Cytochrome c Ions Yield Cation-to-Anion Proton-Transfer Reaction Products with Similar Collision Cross Sections.” JASMS, 2017, 28, 1382-1391. DOI: 10.1007/s13361-017-1620-4

7. Pepin, Robert, Kenneth J. Laszlo, Aleš Marek, Bo Peng, Matthew F. Bush, Helène Lavanant, Carlos Afonso, and František Tureček. “Toward a Rational Design of Highly Folded Peptide Cation Conformations. 3D Gas-Phase Ion Structures and Ion Mobility Characterization.” JASMS, 2016, 27, 1647-1660. DOI: 10.1007/s13361-016-1437-6.

6. Pepin, Robert, Alessio Petrone, Kenneth J. Laszlo, Mathew F. Bush, Xiaosong Li, František Tureček. “Does Thermal Breathing Affect Collision Cross Sections of Gas-Phase Peptide Ions? An Ab Initio Molecular Dynamics Study.” J. Phys. Chem. Lett., 2016, 7, 2765-2771. DOI: 10.1021/acs.jpclett.6b01187

5. Laszlo, Kenneth J., Eleanor B. Munger, and Matthew F. Bush. “Folding of Protein Ions in the Gas Phase after Cation to Anion Proton Transfer Reactions (CAPTR).” JACS, 2016, 138, 9581-9588. DOI: 10.1021/jacs.6b04282

4. Laszlo, Kenneth J., and Matthew F. Bush. “Analysis of Native-Like Proteins and Protein Complexes Using Cation to Anion Proton Transfer Reactions (CAPTR).” JASMS, 2015, 26, 2152–61. DOI: 10.1007/s13361-015-1245-4.

3. Marek, Aleš, Christopher J. Shaffer, Robert Pepin, Kristína Slováková, Kenneth J. Laszlo, Matthew F. Bush, František Tureček. “Electron Transfer Reduction of the Diazirine Ring in Gas-Phase Peptide Ions. On the Peculiar Loss of [NH4O] from Photoleucine.” JASMS, 2014, 26, 415-431. DOI: 10.1007/s13361-014-1047-0

2. Pepin, Robert, Kenneth J. Laszlo, Bo Peng, Aleš Marek, Matthew F. Bush, and František Tureček. “Comprehensive Analysis of Gly-Leu-Gly-Gly-Lys Peptide Dication Structures and Cation-Radical Dissociations Following Electron Transfer: From Electron Attachment to Backbone Cleavage, Ion–Molecule Complexes, and Fragment Separation.” J. Phys. Chem. A, 2014, 118, 308–324. DOI: 10.1021/jp411100c

1. Marek, Aleš, Robert Pepin, Bo Peng, Kenneth J. Laszlo, Matthew F. Bush, and František Tureček. “Electron Transfer Dissociation of Photolabeled Peptides. Backbone Cleavages Compete with Diazirine Ring Rearrangements.” J. Am. Soc. Mass Spectrom., 2013, 24, 1641–1653. DOI: 10.1007/s13361-013-0630-0

Oral Presentations

10. Laszlo, Kenneth J.; Munger, E.B.; Buckner, J.H.; Heard, S.C.; Bush, Matthew F. “Folding Proteins in the Gas-Phase” Georgia Institute of Technology, Atlanta, GA, 03/06/2017

9. Laszlo, Kenneth J.; Munger, E.B.; Heard, S.C.; Bush, Matthew F. “Effects of Charge State on the Structures of Denatured Protein Ions” Cascadia Proteomics Symposium, Seattle, WA, 7/13/2016

8. Laszlo, Kenneth J.; Munger, E.B.; Heard, S.C.; Bush, Matthew F. “Evaluating Gas-Phase Folding of Protein Ions Using Cation to Anion Proton Transfer Reactions” 64nd ASMS Conference on Mass Spectrometry and Allied Topics, San Antonio, TX, 6/6/2016

7. Laszlo, Kenneth J.; Munger, E.B.; Bush, Matthew F. “Using Cation to Anion Proton Transfer Reactions to Probe the Relationship Between Charge and Structure for Protein Ions” 2016 Conference on Ion Chemistry and Mass Spectrometry, Lake Arrowhead, CA, 1/17/2016

6. Laszlo, Kenneth J.; Bush, Matthew F. “Cation to Anion Proton Transfer Reactions of Protein Complexes: Effects of Charge on Structure” ASMS Asilomar Conference on Native Mass Spectrometry-Based Structural Biology, Pacific Grove, CA, 10/20/2015

5. Laszlo, K. J.; Munger, E.B.; Bush, M.F. “On the Folding of Denatured Proteins in the Gas Phase”63rd ASMS Conference on Mass Spectrometry and Allied Topics, Workshop on Gas-Phase Ion Chemistry: Thermodynamics, Kinetics, Structures and Spectroscopy Fundamentals Interest Group, St. Louis, MO, 6/3/2015

4. Laszlo, K. J.; Munger, E.B.; Bush, M.F. “Effects of charge state on the structures of protein ions in the gas phase: Results from ion/ion proton transfer reactions”12th Uppsala Conference on Electron Capture and Transfer Dissociation, Lake Arrowhead, CA, 3/25/2015

3. Laszlo, K. J.; Munger, E.B.; Bush, M.F. “Cation to Anion Proton Transfer Reactions (CAPTR) of Protein Ions: Analytical Utility and Effects of Charge State on Ion Structure”2015 Conference on Ion Chemistry and Mass Spectrometry, Lake Arrowhead, CA, 1/17/2015

2. Laszlo, K. J.; Bush, M.F. “Determining Masses, Separating Mixtures, and Probing Structures of Native-Like Ions using Selected Cation to Anion Proton Transfer (SCAPT)” 62nd ASMS Conference on Mass Spectrometry and Allied Topics, Baltimore, MD, 6/16/2014

1. Laszlo, K. J.; Bush, M.F. “Selected Cation to Anion Proton Transfer” Cascadia Proteomics Symposium, Seattle, WA, 7/16/2013

Poster Presentations

8. Laszlo, Kenneth J.; Munger, E.B.; Heard, S.C.; Bush, Matthew F. “Effects of Charge State on the Structures of Denatured Protein Ions” Cascadia Proteomics Symposium, Seattle, WA, 7/13/2016

7. Laszlo, Kenneth J.; Bush, Matthew F. “Analysis of Native-Like Proteins and Protein Complexes Using Cation to Anion Proton Transfer Reactions (CAPTR)” 2016 Center for Process Analysis and Control (CPAC) Spring Meeting, Seattle, WA, 5/2/2016

6. Laszlo, Kenneth J.; Bush, Matthew F. “Cation to Anion Proton Transfer Reactions of Protein Complexes: Effects of Charge on Structure” ASMS Asilomar Conference on Native Mass Spectrometry-Based Structural Biology, Pacific Grove, CA, 10/19-20/2015

5. Laszlo, Kenneth J.; Munger, E.B., Bush, Matthew F. “Effects of Charge State on the Structures of Protein Ions: Results from Cation to Anion Proton Transfer Reactions” 63rd ASMS Conference on Mass Spectrometry and Allied Topics, St. Louis, MO, 6/3/2015

4. Yen, Gloria; Laszlo, Kenneth J.; Huang, Yue; Heron, Scott; Bush, Matthew F.; Goodlett, David; Nilsson, Erik. “Effects of Charge State on the Structures of Protein Ions: Results from Cation to Anion Proton Transfer Reactions” 63rd ASMS Conference on Mass Spectrometry and Allied Topics, St. Louis, MO, 6/3/2015

3. Laszlo, Kenneth J.; Bush, Matthew F. “Selected Cation to Anion Proton Transfer” Cascadia Proteomics Symposium, Seattle, WA 7/16/13

2. Laszlo, Kenneth J.; Dwivedi, Prabha; Fernandéz, Facundo M., “Ion Mobility Mass Spectrometric Study of Gas-Phase Cyclodextrin-Lipid Inclusion Complexes” American Society for Mass Spectrometry Annual Conference, Vancouver, BC 5/22/12

1. Laszlo, Kenneth J.;Fernandéz, Facundo M., “Cyclodextrins as a Mobility Shift Reagent for the Analysis of Prebiotic Mixtures”, Annual Conference for the Center for Chemical Evolution, Atlanta, GA 8/4/2011